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科研成果

  • 吴梧桐,劳兴珍,郑 珩,李 薇。用酶工程技术生物合成谷胱甘肽的方法, 中国发明专利. 专利号:ZL 200710020902.1
  • 沈秉正,郑珩,劳兴珍,周亚丽。五元杂环双羰基衍生物及其抗多药耐药菌上的用途 中国发明专利,专利号:ZL 201110178082.5
  • 郑珩,王非。含脱落酸的花期延长剂,中国发明专利. 专利号:ZL 200410013999.X
  • 郑珩,廖建民,余永柱,王非。云芝酶解物、其制备方法及其作为酒饮料佐剂的用途,中国发明专利. 专利号:ZL 200510094803.9
  • 余永柱,郑 珩,朱俊卿,等。一种富含木糖适用于发酵生产木糖醇的培养基质的制备方法,中国发明专利,公开号:CN101138413
  • 吴梧桐,劳兴珍,郑珩,李薇, 用酶工程技术生物合成谷胱甘肽的方法.中国发明专利. 专利号:ZL200710020902.1
  • 郑珩、王非译,《生物信息学——从基因组到药物》,化学工业出版社,2006年
  • 郑珩、王非主编,《药物生物信息学》,化工出版社,2004年
  • Lao Xingzhen, Liu Meng, Zhang Fang, Zheng Heng,* Orthogonal Test Design for Optimization of the Expression of Thymosin α1 and Thymosin α1- iRGD Gene in Engineered E.coli BL21 Strain. American Journal of Medical Sciences and Medicine, 2014, Vol. 2, No. 1, 1-6.
  • Jiao Chen, Hui Chen, Tong Zhu, Dandan Zhou, Fang Zhang, Xingzhen Lao*and Heng Zheng* Asp120Asn mutation impairs the catalytic activity of NDM-1 metallo-b-lactamase: experimental and computational study. Phys. Chem. Chem. Phys. 2014, 16, 6709-16
  • Jiao Chen, Xiaohui Shang, Feng Hu, Xingzhen Lao, Xiangdong Gao, Heng Zheng* and Wenbing Yao*. β-Lactamase Inhibitors: An Update. Mini-Reviews in Medicinal Chemistry. 2013, 13(13): 1846-1861.
  • Jiao Chen, Yifang Liu, Mi Fang, Hui Chen, Xingzhen Lao, Xiangdong Gao, Heng Zheng, Wenbing Yao. Combined Support-Vector-Machine-Based Virtual Screening and Docking Method for the Discovery of IMP-1 Metallo-β-Lactamase Inhibitors. American Journal of Biomedical Research. 2013, 1(4): 120-131.
  • Jiao Chen, Hui Chen, Yun Shi, Xiangdong Gao, Heng Zheng, Wenbing Yao. Probing the Effect of the Non-active-site Mutation Y229W in New Delhi Metallo-β-lactamase-1 by Site-directed Mutagenesis, Kinetic Studies, and Molecular Dynamics Simulations. PLoS One. 2013, 8 (12): e82080.
  • Lao X, Liu M, Chen J, Zheng H*. A tumor-penetrating Peptide modification enhances the antitumor activity of thymosin alpha 1. PLoS One. 2013,8(8):e72242.
  • Jiao Chen, Yifang Liu, Tianyi Cheng,Xingzhen Lao, Xiangdong Gao, Heng Zheng*, Wenbing Yao*. A common binding mode that may facilitate the design of novel broadspectrum inhibitors against metallo-β-lactamases. Med Chem Res 2013, DOI 10.1007/s00044- 013-0646-9
  • Shen B, Yu Y, Chen H, Cao X, Lao X, Fang Y, Shi Y, Chen J, Zheng H*. Inhibitor discovery of full-length New Delhi metallo-β-lactamase-1 (NDM-1). PLoS ONE, 2013, 8(5): e62955.
  • Liu JT, Lu XL, Liu XY, Gao Y, Hu B, Jiao BH, Zheng H*. Bioactive Natural Products from the Antarctic and Arctic Organisms. Mini-Reviews in Medicinal Chemistry, 2013, 13, 617-626
  • Jiao Chen, Rong Yu, Bingzheng Shen, Yan Xu, Yifang Liu, Heng Zheng* and Wenbing Yao*. Docking-based 3D-QSAR modeling of the inhibitors of IMP metallo-β-lactamase. Medicinal Chemistry Research 2013, 22(4):1730-1739
  • Pu, Chun-yan ; Xu, Han-mei ; Hu, Jia-liang ; Zheng, Heng ; Huang, Xiao-feng ; Zhang, Chi ; Yang, Yong-jing ; Li, Yong-bing. RGD-modified endostatin fragments showed an antitumor effect through antiangiogenesis.Anti-Cancer Drugs.2012, 23(8):788-802
  • Yujie Dai*, Qiang Wang, Xiuli Zhang, Shiru Jia, Heng Zheng, Dacheng Feng, Peng Yu. Molecular docking and QSAR study on steroidal compounds as aromatase inhibitors. European Journal of Medicinal Chemistry 2010,45: 5612-5620
  • Renhua Sun, Heng Zheng*, Zhengzhi Fang, Wenbing Yao*. Rational design of aminoacyl-tRNA synthetase specific for p-acetyl-L-phenylalanine. Biochemical and Biophysical Research Communications 2010,391(1): 709~715
  • Runting Yin, Heng Zheng, Tao Xi, and Han-Mei Xu. Effect of RGD-4C Position is More Important Than Disulfide Bonds on Antiangiogenic Activity of RGD-4C Modified Endostatin Derived Synthetic Polypeptide. Bioconjugate Chem. 2010, 21, 1142–1147
  • Meiling Lu, Xu Cao, Xin Yang, Heng Zheng, Nan Liu, Yun Jiang,Donghai Lin,Yijun Chen.. A diketoreductase exhibits unique renaturation profile from thermal-induced protein unfolding. Amino Acids, 2010,39(2):609-613
  • Nakajima Y, Ito K, Toshima T, Egawa T, Zheng H, Oyama H, Wu YF, Takahashi E, Kyono K, Yoshimoto T. Dipeptidyl aminopeptidase IV from Stenotrophomonas maltophilia exhibits activity against a substrate containing a 4-hydroxyproline residue. J Bacteriol. 2008, 190(23): 7819-29
  • Xu Y, Nakajima Y, Ito K, Zheng H et al. Novel inhibitor for prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate-recognition mechanism. J Mol Biol. 2008,375(3):708-719
  • Heng Zheng, Yue Xu, Yoshitaka Nakajima, Kiyoshi Ito, Tadashi Yoshimoto. Enzymatic study and crystallization of aminopeptidase P from Porphyromonas gingivalis. 13th symposium of The Society for Biotechnology of Japan in Kyushu (2006): 53
  • YE Qin-yuan, ZHENG Heng, WANG Min,et al. Molecular cloning, expression and purification of the SARS coronavirus main protease 3Clpro. Pharmaceutical Biotechnology 2005, 12(4): 219~223
  • 周美峰,乌兰,房咪,郑珩*;基于结构的香农熵及其在金属β-内酰胺酶结构分析中的应用研究。抗感染药学,2012,9(3):187
  • 陈灵犀; 郑珩*;蛋白质-配体亲和性预测研究进展. 药物生物技术. 2010, 17( 6) : 545~ 550
  • 鲁延迅,郑珩*,周俊; 应用球面对称设计方法优化谷胱甘肽生物合成条件. 氨基酸和生物资源 2010, 32( 2 ) : 45~ 48
  • 陈照强,刘一方,陈姣,周美峰,郑珩*; 抗击超级细菌:耐药酶的起源研究和变异预测. 抗感染药学,2011,8(3):154
  • 陈照强, 刘一方, 朱 宁, 陈姣, 郑珩*;金属β-内酰胺酶的研究进展. 国外医药抗生素分册, 2011,32(3):111
  • 沈秉正,郑珩,倪孟祥,顾觉奋*; B型金属β-内酰胺酶抑制剂研究进展. 中国新药杂志. 2011, 20(2): 143~147
  • 吕品一,郑珩*,劳兴珍. 蛋白质共进化分析研究进展. 生物信息学,2010,8(10):34~35
  • 吕燕妮,郑珩,何华. PAMAM树状大分子与加替沙星相互作用的分子模拟研究. 药物生物技术,2010,17(1):56~61
  • 许岩,余江河,郑珩*,劳兴珍,吕品一。IMP型金属β-内酰胺酶活性中心的计算机模拟分析。中国抗生素杂志2009,34(9):483~487
  • 劳兴珍,卞芙蓉,杨士彦,郑珩*; pH及流加葡萄糖对酵母分批发酵生产谷胱甘肽的影响. 氨基酸与生物资源 2009,31(4):43~45
  • 徐雯,曹艳华,乔德水,郑珩,孔毅,吴梧桐;α-葡萄糖苷酶三维结构的同源模建及其对接研究. 药物生物技术 2009,16(3):255~259
  • 卞芙蓉,劳兴珍,郑珩*,吴梧桐。酵母发酵生产谷胱甘肽的培养基优化。中国生化药物杂志 2009,30(3):184~186
  • 叶波平,潘征,李怀标,王颖,郑珩,吴梧桐。鲨肝刺激物质类似物在大肠杆菌中的高密度发酵。生物工程学报 2009,25(9):1371-1378
  • 尹鸿萍,郑震寰,郑珩,王旻*。钝顶螺旋藻酸性多糖的分离纯化和结构分析。中国医药工业杂志 2009,40(12):16
  • 王乐希,郑珩*,劳兴珍. 蛋白质分子柔性对接方法研究进展. 药物生物技术2008,15(4):302~306
  • 肖开芳,李薇,郑珩*,吴梧桐. 谷胱甘肽生物合成途径及发酵条件研究. 中国生化药物杂志 2008,29(2):144~146
  • 李薇,劳兴珍,郑珩*,吴梧桐. 高产谷胱甘肽酵母菌的诱变选育以及发酵条件的初步研究. 药物生物技术2008 ,15 (1) :48~50
  • Lao Xingzhen, Liu Meng, Zhang Fang, Zheng Heng,* Orthogonal Test Design for Optimization of the Expression of Thymosin α1 and Thymosin α1- iRGD Gene in Engineered E.coli BL21 Strain. American Journal of Medical Sciences and Medicine, 2014, Vol. 2, No. 1, 1-6
  • Jiao Chen, Hui Chen, Tong Zhu, Dandan Zhou, Fang Zhang, Xingzhen Lao*and Heng Zheng* Asp120Asn mutation impairs the catalytic activity of NDM-1 metallo-b-lactamase: experimental and computational study. Phys. Chem. Chem. Phys. 2014, 16, 6709-16
  • Jiao Chen, Xiaohui Shang, Feng Hu, Xingzhen Lao, Xiangdong Gao, Heng Zheng* and Wenbing Yao*. β-Lactamase Inhibitors: An Update. Mini-Reviews in Medicinal Chemistry. 2013, 13(13): 1846-1861
  • Lao X, Liu M, Chen J, Zheng H*. A tumor-penetrating Peptide modification enhances the antitumor activity of thymosin alpha 1. PLoS One. 2013,8(8):e72242.
  • Jiao Chen, Yifang Liu, Tianyi Cheng,Xingzhen Lao, Xiangdong Gao, Heng Zheng*, Wenbing Yao*. A common binding mode that may facilitate the design of novel broadspectrum inhibitors against metallo-β-lactamases. Med Chem Res 2013, DOI 10.1007/s00044- 013-0646-9
  • 劳兴珍,汤慧,吴国球,郑珩. 抗栓肽基因的克隆和表达 药物生物技术 2006,Vol.13(3):174-177
  • 劳兴珍,吴国球, 何赟绵, 沈子龙. 心肌肌钙蛋白I的融合表达和分离纯化 中国生化药物杂志 2006,Vol.27(3):150-152
  • 汤慧,劳兴珍,郑珩 抗栓肽Ala34→Trp突变体表达及活性研究 中国药科大学学报,2007年,38(6):218-220
  • 劳兴珍,吴梧桐 基于结构设计的鼻病毒3C蛋白酶抑制剂的研究进展 药物生物技术 2007年,14(3):218-220
  • 劳兴珍, 卞芙蓉, 杨士彦, 郑 珩. pH及流加葡萄糖对酵母分批发酵生产谷胱甘肽的影响 氨基酸和生物资源,2009,31(4):43-45

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